References

• Farasat S, Aksentijevich I, Toro JR. Autoinflammatory diseases: clinical and genetic advances. Arch Dermatol. 2008;144(3):392-402.
• Data on file. Novartis Pharmaceuticals Corporation.
• Durrant KLW, Goldbach-Mansky R, Hoffman H, Leslie K, Rubin B. CAPS: cryopyrinassociated periodic syndromes. San Francisco, CA: The NOMID Alliance; 2008.
• Hoffman HM. Hereditary immunologic disorders caused by pyrin and cryopyrin. Curr Allergy Asthma Rep. 2007;7(5):323-330.
• Stych B, Dobrovolny D. Familial cold auto-inflammatory syndrome (FCAS): characterization of symptomatology and impact on patients' lives. Curr Med Res Opin.2008;24(6):1577-1582.
• Shinkai K, McCalmont TH, Leslie KS. Cryopyrin-associated periodic syndromes and autoinflammation. Clin Exp Dermatol. 2007;33(1):1-9.
• Familial Cold Autoinflammatory Syndrome (FCAS). The NOMID Alliance Web site. http://www.nomidalliance.net/subpage1.html. Accessed on April 13, 2009.
• Muckle TJ, Wells M. Urticaria, deafness and amyloidosis: a new heredo-familial syndrome. QJM. 1962;31:235-248.
• Boschan C, Witt O, Lohse P, Foeldvari I, Zappel H, Schweigerer L. Clinical report:neonatal-onset multisystem inflammatory disease (NOMID) due to a novel s331r mutation of the CIAS1 gene and response to interleukin-1 receptor antagonist treatment. Am J Med Genet. 2006;140A:883-886.
• Gattorno M, Federici S, Pelagatti MA, et al. Diagnosis and management of autoinflammatory diseases in childhood. J Clin Immunol. 2008;28 (suppl 1):S73-S83.
• Prieur AM, Griscelli C, Lampert F, et al. A chronic infantile neurological cutaneous and articular (CINCA) syndrome: a specific entity analysed in 30 patients. Scand J Rheumatol Suppl. 1987;66:57-68.
• Watts RA, Nicholls A, Scott DGI. Case report: the arthropathy of the Muckle-Wells syndrome. Br J Rheumatol. 1994;33(12):1184-1187.

• Overview
• About CAPS
• CAPS - Treatments, Symptoms and Patient Story
• FCAS - Facts, Symptoms and Patient Story
• MWS - Facts, Symptoms and Patient Story
• NOMID - Facts and Symptoms

• Download the CAPS Patient booklet
• References

FCAS – Familial Cold Autoinflammatory Syndrome
It can also be called FCAIS or FCU, which stands for Familial Cold Urticaria. People with FCAS usually start having symptoms from birth. Occasionally, symptoms may start later in childhood. Symptoms of FCAS can begin after a person is exposed to cold temperature. » Learn More

MWS - Muckle-Wells Syndrome
MWS was first recognised in a family in the early 1960s by 2 doctors named Thomas James Muckle and Michael Vernon Wells. Like FCAS, people with MWS usually start having symptoms from birth. Occasionally, symptoms may start later in childhood. Symptoms can occur without any obvious reason.
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NOMID - Neonatal-Onset Multisystem Inflammatory Disease
NOMID can also be called CINCA, which stands for Chronic Infantile Neurological Cutaneous Articular Syndrome. NOMID/CINCA is the most severe type of CAPS. People with NOMID/CINCA almost always start having symptoms from birth. A doctor may diagnose NOMID/CINCA quickly in a newborn because symptoms are often more noticeable than in FCAS or MWS. » Learn More